SISTEMA ENDÓCRINO QUÂNTICO

1. Bayliss, W.M., & Starling, E.H. (1902). “The mechanism of pancreatic secretion.” Journal of Physiology, 28(5), 325-353.
2. Banting, F.G., Best, C.H., Collip, J.B., Campbell, W.R., & Fletcher, A.A. (1922). “Pancreatic extracts in the treatment of diabetes mellitus.” Canadian Medical Association Journal, 12(3), 141-146.
3. Brown-Séquard, C.E. (1889). “The effects produced on man by subcutaneous injections of a liquid obtained from the testicles of animals.” The Lancet, 134(3438), 105-107.

Cronobiologia e Ritmos Circadianos

4. Hall, J.C., Rosbash, M., & Young, M.W. (2017). Nobel Prize in Physiology or Medicine for discoveries of molecular mechanisms controlling circadian rhythm.
5. Partch, C.L., Green, C.B., & Takahashi, J.S. (2014). “Molecular architecture of the mammalian circadian clock.” Trends in Cell Biology, 24(2), 90-99.
6. Hastings, M.H., Maywood, E.S., & Brancaccio, M. (2018). “Generation of circadian rhythms in the suprachiasmatic nucleus.” Nature Reviews Neuroscience, 19(8), 453-469.

Epigenética Endócrina

7. Meaney, M.J., & Szyf, M. (2005). “Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.” Dialogues in Clinical Neuroscience, 7(2), 103-123.
8. Weaver, I.C., Cervoni, N., Champagne, F.A., D’Alessio, A.C., Sharma, S., Seckl, J.R., … & Meaney, M.J. (2004). “Epigenetic programming by maternal behavior.” Nature Neuroscience, 7(8), 847-854.
9. Bale, T.L. (2015). “Epigenetic and transgenerational reprogramming of brain development.” Nature Reviews Neuroscience, 16(6), 332-344.

Física Quântica e Biofótons

10. Popp, F.A., Warnke, U., König, H.L., & Peschka, W. (1989). “Electromagnetic bio-information.” Urban & Schwarzenberg.
11. Van Wijk, R., Van Wijk, E.P., Wiegant, F.A., & Ives, J. (2008). “Free radicals and low-level photon emission in human pathogenesis: state of the art.” Indian Journal of Experimental Biology, 46(5), 273-309.
12. Cifra, M., & Fields, J.Z. (2011). “Cellular signaling via electrostatic interactions and what it means for biology.” BMC Biophysics, 4(1), 1-11.

Diabetes e Metabolismo

13. DeFronzo, R.A. (1988). “Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.” Diabetes, 37(6), 667-687.
14. International Diabetes Federation (2021). IDF Diabetes Atlas, 10th edition.
15. Kahn, S.E., Cooper, M.E., & Del Prato, S. (2014). “Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future.” The Lancet, 383(9922), 1068-1083.

Doenças da Tireoide

16. Hollowell, J.G., Staehling, N.W., Flanders, W.D., et al. (2002). “Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III).” Journal of Clinical Endocrinology & Metabolism, 87(2), 489-499.
17. Chaker, L., Bianco, A.C., Jonklaas, J., & Peeters, R.P. (2017). “Hypothyroidism.” The Lancet, 390(10101), 1550-1562.
18. Wiersinga, W.M. (2014). “Clinical relevance of environmental factors in the pathogenesis of autoimmune thyroid disease.” Endocrinology and Metabolism Clinics, 43(2), 277-293.

SISTEMA ENDOCANABINOIDE CONSCIENTE

Descoberta do Sistema

19. Devane, W.A., Hanus, L., Breuer, A., Pertwee, R.G., Stevenson, L.A., Griffin, G., … & Mechoulam, R. (1992). “Isolation and structure of a brain constituent that binds to the cannabinoid receptor.” Science, 258(5090), 1946-1949.
20. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., Young, A.C., & Bonner, T.I. (1990). “Structure of a cannabinoid receptor and functional expression of the cloned cDNA.” Nature, 346(6284), 561-564.
21. Mechoulam, R., Ben-Shabat, S., Hanus, L., et al. (1995). “Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.” Biochemical Pharmacology, 50(1), 83-90.

Sistema Endocanabinoide e Homeostase

22. Di Marzo, V., & Piscitelli, F. (2015). “The endocannabinoid system and its modulation by phytocannabinoids.” Neurotherapeutics, 12(4), 692-698.
23. Pertwee, R.G. (2006). “The pharmacology of cannabinoid receptors and their ligands: an overview.” International Journal of Obesity, 30(S1), S13-S18.
24. Castillo, P.E., Younts, T.J., Chávez, A.E., & Hashimotodani, Y. (2012). “Endocannabinoid signaling and synaptic function.” Neuron, 76(1), 70-81.

Deficiência Endocanabinoide Clínica

25. Russo, E.B. (2016). “Clinical endocannabinoid deficiency reconsidered: current research supports the theory in migraine, fibromyalgia, irritable bowel, and other treatment-resistant syndromes.” Cannabis and Cannabinoid Research, 1(1), 154-165.
26. Russo, E.B. (2004). “Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?” Neuro Endocrinology Letters, 25(1-2), 31-39.

Neuroproteção e BDNF

27. Marsicano, G., & Lutz, B. (2006). “Neuromodulatory functions of the endocannabinoid system.” Journal of Endocrinological Investigation, 29(3 Suppl), 27-46.
28. Aguado, T., Palazuelos, J., Monory, K., et al. (2006). “The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells.” Journal of Neuroscience, 26(5), 1551-1561.

Inflamação e Imunorregulação

29. Klein, T.W. (2005). “Cannabinoid-based drugs as anti-inflammatory therapeutics.” Nature Reviews Immunology, 5(5), 400-411.
30. Nagarkatti, P., Pandey, R., Rieder, S.A., Hegde, V.L., & Nagarkatti, M. (2009). “Cannabinoids as novel anti-inflammatory drugs.” Future Medicinal Chemistry, 1(7), 1333-1349.

Efeito Entourage

31. Russo, E.B. (2011). “Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.” British Journal of Pharmacology, 163(7), 1344-1364.
32. Ferber, S.G., Namdar, D., Hen-Shoval, D., et al. (2020). “The ‘entourage effect’: terpenes coupled with cannabinoids for the treatment of mood disorders and anxiety disorders.” Current Neuropharmacology, 18(2), 87-96.

SISTEMA DE ÓRGÃOS FÍSICOS E CAMPOS QUÂNTICOS

Coração e Campo Eletromagnético

33. McCraty, R., Atkinson, M., Tomasino, D., & Bradley, R.T. (2009). “The coherent heart: Heart-brain interactions, psychophysiological coherence, and the emergence of system-wide order.” Integral Review, 5(2), 10-115.
34. McCraty, R., & Childre, D. (2010). “Coherence: Bridging personal, social, and global health.” Alternative Therapies in Health and Medicine, 16(4), 10-24.

Biofísica Cardiovascular

35. Zamir, M. (2016). Hemo-Dynamics. Springer International Publishing.
36. Nichols, W.W., & O’Rourke, M.F. (2005). McDonald’s Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. 5th ed. London: Hodder Arnold.

Biofótons e Comunicação Celular

37. Popp, F.A. (2003). “Properties of biophotons and their theoretical implications.” Indian Journal of Experimental Biology, 41(5), 391-402.
38. Van Wijk, R., Kobayashi, M., & Van Wijk, E.P. (2006). “Anatomic characterization of human ultra-weak photon emission with a moveable photomultiplier and CCD imaging.” Journal of Photochemistry and Photobiology B: Biology, 83(1), 69-76.

Ressonância Schumann

39. König, H.L. (1974). “Behavioural changes in human subjects associated with ELF electric fields.” Persinger MA (ed). ELF and VLF Electromagnetic Field Effects, New York: Plenum Press.
40. Cherry, N. (2002). “Schumann resonances, a plausible biophysical mechanism for the human health effects of solar.” Natural Hazards, 26(3), 279-331.

Água Estruturada

41. Pollack, G.H. (2013). The Fourth Phase of Water: Beyond Solid, Liquid, and Vapor. Ebner & Sons Publishers.
42. Pollack, G.H., & Figueroa, X. (2009). “Molecules, water, and radiant energy: new clues for the origin of life.” International Journal of Molecular Sciences, 10(4), 1419-1429.

Doenças Cardiovasculares

43. Kannel, W.B. (2000). “Elevated systolic blood pressure as a cardiovascular risk factor.” American Journal of Cardiology, 85(2), 251-255.
44. Yancy, C.W., Jessup, M., Bozkurt, B., et al. (2013). “2013 ACCF/AHA guideline for the management of heart failure.” Circulation, 128(16), e240-e327.
45. Libby, P., Ridker, P.M., & Hansson, G.K. (2011). “Progress and challenges in translating the biology of atherosclerosis.” Nature, 473(7347), 317-325.
    
    46. Merzenich, M.M., Van Vleet, T.M., & Nahum, M. (2014). “Brain plasticity-based therapeutics.” Frontiers in Human Neuroscience, 8, 385.
    47. Doidge, N. (2007). The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science. Penguin Books.
    48. Kolb, B., & Whishaw, I.Q. (1998). “Brain plasticity and behavior.” Annual Review of Psychology, 49(1), 43-64.

    Teoria Orch-OR

    49. Penrose, R., & Hameroff, S. (2011). “Consciousness in the universe: Neuroscience, quantum space-time geometry and Orch OR theory.” Journal of Cosmology, 14, 1-17.
    50. Hameroff, S., & Penrose, R. (2014). “Consciousness in the universe: A review of the ‘Orch OR’ theory.” Physics of Life Reviews, 11(1), 39-78.

51. Carlsson, A. (2001). “A paradigm shift in brain research.” Science, 294(5544), 1021-1024.
52. Kandel, E.R., Schwartz, J.H., & Jessell, T.M. (2000). Principles of Neural Science. 4th ed. McGraw-Hill.

Alzheimer e Degeneração

53. Jack, C.R., et al. (2018). “NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease.” Alzheimer’s & Dementia, 14(4), 535-562.
54. Selkoe, D.J., & Hardy, J. (2016). “The amyloid hypothesis of Alzheimer’s disease at 25 years.” EMBO Molecular Medicine, 8(6), 595-608.

Parkinson

55. Kalia, L.V., & Lang, A.E. (2015). “Parkinson’s disease.” The Lancet, 386(9996), 896-912.
56. Lees, A.J., Hardy, J., & Revesz, T. (2009). “Parkinson’s disease.” The Lancet, 373(9680), 2055-2066.

Esclerose Múltipla

57. Compston, A., & Coles, A. (2008). “Multiple sclerosis.” The Lancet, 372(9648), 1502-1517.
58. Hemmer, B., Kerschensteiner, M., & Korn, T. (2015). “Role of the innate and adaptive immune responses in the course of multiple sclerosis.” The Lancet Neurology, 14(4), 406-419.

SENTIDOS FÍSICOS E EXTRA-SENSORIAIS

Magnetorrecepção Humana

59. Wang, C.X., Hilburn, I.A., Wu, D.A., et al. (2019). “Transduction of the geomagnetic field as evidenced from alpha-band activity in the human brain.” eNeuro, 6(2).
60. Foley, L.E., Gegear, R.J., & Reppert, S.M. (2011). “Human cryptochrome exhibits light-dependent magnetosensitivity.” Nature Communications, 2(1), 1-3.

Percepção Extra-Sensorial

61. Rhine, J.B. (1934). Extra-Sensory Perception. Boston Society for Psychic Research.
62. Radin, D.I. (1997). The Conscious Universe: The Scientific Truth of Psychic Phenomena. HarperOne.
63. Bem, D.J. (2011). “Feeling the future: experimental evidence for anomalous retroactive influences on cognition and affect.” Journal of Personality and Social Psychology, 100(3), 407-425.

Sinestesia

64. Ramachandran, V.S., & Hubbard, E.M. (2001). “Synaesthesia–a window into perception, thought and language.” Journal of Consciousness Studies, 8(12), 3-34.
65. Cytowic, R.E. (2018). Synesthesia. MIT Press.

Asma e DPOC

66. Global Initiative for Asthma (GINA). (2023). Global Strategy for Asthma Management and Prevention.
67. Vogelmeier, C.F., Criner, G.J., Martinez, F.J., et al. (2017). “Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report.” American Journal of Respiratory and Critical Care Medicine, 195(5), 557-582.

LEITOR QUÂNTICO DE PADRÕES INTEGRADOS

Teoria da Informação Biológica

68. Shannon, C.E. (1948). “A mathematical theory of communication.” Bell System Technical Journal, 27(3), 379-423.
69. Nurse, P. (2008). “Life, logic and information.” Nature, 454(7203), 424-426.

Epigenética Transgeracional

70. Skinner, M.K. (2015). “Environmental epigenetics and a unified theory of the molecular aspects of evolution: a neo-lamarckian concept that facilitates neo-Darwinian evolution.” Genome Biology and Evolution, 7(5), 1296-1302.
71. Jablonka, E., & Raz, G. (2009). “Transgenerational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution.” The Quarterly Review of Biology, 84(2), 131-176.

Microbioma

72. Lynch, S.V., & Pedersen, O. (2016). “The human intestinal microbiome in health and disease.” New England Journal of Medicine, 375(24), 2369-2379.
73. Cryan, J.F., O’Riordan, K.J., Cowan, C.S., et al. (2019). “The microbiota-gut-brain axis.” Physiological Reviews, 99(4), 1877-2013.

Fascia

74. Schleip, R., Findley, T.W., Chaitow, L., & Huijing, P. (2012). Fascia: The Tensional Network of the Human Body. Elsevier Health Sciences.
75. Stecco, C., & Hammer, W.I. (2015). Functional Atlas of the Human Fascial System. Elsevier Health Sciences.

Trauma Somático

76. Levine, P.A. (1997). Waking the Tiger: Healing Trauma. North Atlantic Books.
77. Van der Kolk, B. (2014). The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma. Penguin Books.

Síndrome do Intestino Irritável

78. Drossman, D.A., & Hasler, W.L. (2016). “Rome IV—functional GI disorders: disorders of gut-brain interaction.” Gastroenterology, 150(6), 1257-1261.
79. Enck, P., Aziz, Q., Barbara, G., et al. (2016). “Irritable bowel syndrome.” Nature Reviews Disease Primers, 2(1), 1-24.

LABORATÓRIO QUÂNTICO DE CERTIFICAÇÃO

Variabilidade da Frequência Cardíaca

80. Task Force of the European Society of Cardiology. (1996). “Heart rate variability: standards of measurement, physiological interpretation, and clinical use.” Circulation, 93(5), 1043-1065.
81. Shaffer, F., & Ginsberg, J.P. (2017). “An overview of heart rate variability metrics and norms.” Frontiers in Public Health, 5, 258.

Bioimpedância

82. Kyle, U.G., Bosaeus, I., De Lorenzo, A.D., et al. (2004). “Bioelectrical impedance analysis—part I: review of principles and methods.” Clinical Nutrition, 23(5), 1226-1243.

Termografia Médica

83. Ring, E.F.J., & Ammer, K. (2012). “Infrared thermal imaging in medicine.” Physiological Measurement, 33(3), R33.
84. Brioschi, M.L., Macedo, J.F., & Macedo, R.A.C. (2003). “Skin thermometry: new concepts.” Jornal Vascular Brasileiro, 2(2), 151-160.

Metabolômica

85. Wishart, D.S. (2016). “Emerging applications of metabolomics in drug discovery and precision medicine.” Nature Reviews Drug Discovery, 15(7), 473-484.
86. Johnson, C.H., Ivanisevic, J., & Siuzdak, G. (2016). “Metabolomics: beyond biomarkers and towards mechanisms.” Nature Reviews Molecular Cell Biology, 17(7), 451-459.

Fibromialgia

87. Clauw, D.J. (2014). “Fibromyalgia: a clinical review.” JAMA, 311(15), 1547-1555.
88. Häuser, W., Ablin, J., Fitzcharles, M.A., et al. (2015). “Fibromyalgia.” Nature Reviews Disease Primers, 1(1), 1-16.

Osteoporose

89. NIH Consensus Development Panel. (2001). “Osteoporosis prevention, diagnosis, and therapy.” JAMA, 285(6), 785-795.
90. Compston, J.E., McClung, M.R., & Leslie, W.D. (2019). “Osteoporosis.” The Lancet, 393(10169), 364-376.

TERAPIAS INTEGRATIVAS E PROTOCOLOS QUÂNTICOS

Fitoterapia e Adaptógenos

91. Panossian, A., & Wikman, G. (2010). “Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress—protective activity.” Pharmaceuticals, 3(1), 188-224.
92. Singh, N., Bhalla, M., de Jager, P., & Gilca, M. (2011). “An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda.” African Journal of Traditional, Complementary and Alternative Medicines, 8(5S).

Meditação e Neuroplasticidade

93. Davidson, R.J., & Lutz, A. (2008). “Buddha’s brain: Neuroplasticity and meditation.” IEEE Signal Processing Magazine, 25(1), 176-174.
94. Tang, Y.Y., Hölzel, B.K., & Posner, M.I. (2015). “The neuroscience of mindfulness meditation.” Nature Reviews Neuroscience, 16(4), 213-225.

EFT (Emotional Freedom Technique)

95. Church, D., Yount, G., & Brooks, A.J. (2012). “The effect of emotional freedom techniques on stress biochemistry: A randomized controlled trial.” Journal of Nervous and Mental Disease, 200(10), 891-896.
96. Feinstein, D. (2012). “Acupoint stimulation in treating psychological disorders: Evidence of efficacy.” Review of General Psychology, 16(4), 364-380.

EMDR

97. Shapiro, F. (2014). “The role of eye movement desensitization and reprocessing (EMDR) therapy in medicine: addressing the psychological and physical symptoms stemming from adverse life experiences.” The Permanente Journal, 18(1), 71.
98. World Health Organization. (2013). Guidelines for the Management of Conditions Specifically Related to Stress. WHO.

Acupuntura

99. Han, J.S. (2004). “Acupuncture and endorphins.” Neuroscience Letters, 361(1-3), 258-261.
100. Vickers, A.J., Vertosick, E.A., Lewith, G., et al. (2018). “Acupuncture for chronic pain: update of an individual patient data meta-analysis.” The Journal of Pain, 19(5), 455-474.

ESTUDOS ADICIONAIS (101-200)

Ômega-3 e Sistema Endocanabinoide

101. Watanabe, S., Doshi, M., & Hamazaki, T. (2003). “n-3 Polyunsaturated fatty acid (PUFA) deficiency elevates and n-3 PUFA enrichment reduces brain 2-arachidonoylglycerol level in mice.” Prostaglandins, Leukotrienes and Essential Fatty Acids, 69(1), 51-59.
102. Simopoulos, A.P. (2016). “An increase in the omega-6/omega-3 fatty acid ratio increases the risk for obesity.” Nutrients, 8(3), 128.

Probióticos e Eixo Intestino-Cérebro

103. Dinan, T.G., & Cryan, J.F. (2017). “The microbiome-gut-brain axis in health and disease.” Gastroenterology Clinics, 46(1), 77-89.
104. Mohajeri, M.H., La Fata, G., Steinert, R.E., & Weber, P. (2018). “Relationship between the gut microbiome and brain function.” Nutrition Reviews, 76(7), 481-496.

Cetose e Neuroproteção

105. Newport, M.T., VanItallie, T.B., Kashiwaya, Y., King, M.T., & Veech, R.L. (2015). “A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer’s disease.” Alzheimer’s & Dementia, 11(1), 99-103.
106. Paoli, A., Bianco, A., Damiani, E., & Bosco, G. (2014). “Ketogenic diet in neuromuscular and neurodegenerative diseases.” BioMed Research International, 2014.

Estimulação Magnética Transcraniana

107. O’Reardon, J.P., Solvason, H.B., Janicak, P.G., et al. (2007). “Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial.” Biological Psychiatry, 62(11), 1208-1216.
108. Lefaucheur, J.P., André-Obadia, N., Antal, A., et al. (2014). “Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS).” Clinical Neurophysiology, 125(11), 2150-2206.

Oxigenoterapia Hiperbárica

109. Efrati, S., Fishlev, G., Bechor, Y., et al. (2013). “Hyperbaric oxygen induces late neuroplasticity in post stroke patients–randomized, prospective trial.” PloS One, 8(1), e53716.
110. Harch, P.G., & McCullough, V. (2010). The Oxygen Revolution: Hyperbaric Oxygen Therapy. Hatherleigh Press.

Earthing/Grounding

311. Pacher, P., Bátkai, S., & Kunos, G. (2006). “The endocannabinoid system as an emerging target of pharmacotherapy.” Pharmacological Reviews, 58(3), 389-462.
312. Di Marzo, V. (2018). “New approaches and challenges to targeting the endocannabinoid system.” Nature Reviews Drug Discovery, 17(9), 623-639.
313. Lu, H.C., & Mackie, K. (2016). “An introduction to the endogenous cannabinoid system.” Biological Psychiatry, 79(7), 516-525.
314. Pertwee, R.G. (2015). “Endocannabinoids and their pharmacological actions.” Handbook of Experimental Pharmacology, 231, 1-37.
315. Zou, S., & Kumar, U. (2018). “Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system.” International Journal of Molecular Sciences, 19(3), 833.
316. Hillard, C.J. (2018). “Circulating endocannabinoids: from whence do they come and where are they going?” Neuropsychopharmacology, 43(1), 155-172.
317. Maccarrone, M., Bab, I., Bíró, T., et al. (2015). “Endocannabinoid signaling at the periphery: 50 years after THC.” Trends in Pharmacological Sciences, 36(5), 277-296.
318. Ligresti, A., De Petrocellis, L., & Di Marzo, V. (2016). “From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology.” Physiological Reviews, 96(4), 1593-1659.
319. Stella, N. (2010). “Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas.” Glia, 58(9), 1017-1030.
320. Walter, L., Franklin, A., Witting, A., Wade, C., Xie, Y., Kunos, G., … & Stella, N. (2003). “Nonpsychotropic cannabinoid receptors regulate microglial cell migration.” Journal of Neuroscience, 23(4), 1398-1405.
321. Guindon, J., & Hohmann, A.G. (2009). “The endocannabinoid system and pain.” CNS & Neurological Disorders-Drug Targets, 8(6), 403-421.
322. Fine, P.G., & Rosenfeld, M.J. (2013). “The endocannabinoid system, cannabinoids, and pain.” Rambam Maimonides Medical Journal, 4(4), e0022.
323. Woodhams, S.G., Chapman, V., Finn, D.P., Hohmann, A.G., & Neugebauer, V. (2017). “The cannabinoid system and pain.” Neuropharmacology, 124, 105-120.
324. Pacher, P., & Kunos, G. (2013). “Modulating the endocannabinoid system in human health and disease–successes and failures.” The FEBS Journal, 280(9), 1918-1943.
325. Iannotti, F.A., Di Marzo, V., & Petrosino, S. (2016). “Endocannabinoids and endocannabinoid-related mediators: targets, metabolism and role in neurological disorders.” Progress in Lipid Research, 62, 107-128.
326. Cabral, G.A., Rogers, T.J., & Lichtman, A.H. (2015). “Turning over a new leaf: cannabinoid and endocannabinoid modulation of immune function.” Journal of Neuroimmune Pharmacology, 10(2), 193-203.
327. Pandey, R., Mousawy, K., Nagarkatti, M., & Nagarkatti, P. (2009). “Endocannabinoids and immune regulation.” Pharmacological Research, 60(2), 85-92.
328. Turcotte, C., Blanchet, M.R., Laviolette, M., & Flamand, N. (2016). “The CB2 receptor and its role as a regulator of inflammation.” Cellular and Molecular Life Sciences, 73(23), 4449-4470.
329. Berdyshev, E.V. (2000). “Cannabinoid receptors and the regulation of immune response.” Chemistry and Physics of Lipids, 108(1-2), 169-190.
330. Burstein, S. (2015). “Cannabidiol (CBD) and its analogs: a review of their effects on inflammation.” Bioorganic & Medicinal Chemistry, 23(7), 1377-1385.
331. Nagarkatti, P., Pandey, R., Rieder, S.A., Hegde, V.L., & Nagarkatti, M. (2009). “Cannabinoids as novel anti-inflammatory drugs.” Future Medicinal Chemistry, 1(7), 1333-1349.
332. Turcotte, C., Chouinard, F., Lefebvre, J.S., & Flamand, N. (2015). “Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites.” Journal of Leukocyte Biology, 97(6), 1049-1070.
333. Rieder, S.A., Chauhan, A., Singh, U., Nagarkatti, M., & Nagarkatti, P. (2010). “Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.” Immunobiology, 215(8), 598-605.
334. McPartland, J.M., Guy, G.W., & Di Marzo, V. (2014). “Care and feeding of the endocannabinoid system: a systematic review of potential clinical interventions that upregulate the endocannabinoid system.” PloS One, 9(3), e89566.
335. Hill, K.P., Palastro, M.D., Johnson, B., & Ditre, J.W. (2017). “Cannabis and pain: a clinical review.” Cannabis and Cannabinoid Research, 2(1), 96-104.
336. Blake, D.R., Robson, P., Ho, M., Jubb, R.W., & McCabe, C.S. (2006). “Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis.” Rheumatology, 45(1), 50-52.
337. Notcutt, W., Price, M., Miller, R., et al. (2004). “Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 ‘N of 1’ studies.” Anaesthesia, 59(5), 440-452.
338. Ware, M.A., Wang, T., Shapiro, S., et al. (2010). “Smoked cannabis for chronic neuropathic pain: a randomized controlled trial.” CMAJ, 182(14), E694-E701.
339. Wilsey, B., Marcotte, T., Deutsch, R., Gouaux, B., Sakai, S., & Donaghe, H. (2013). “Low-dose vaporized cannabis significantly improves neuropathic pain.” The Journal of Pain, 14(2), 136-148.
340. Lynch, M.E., & Campbell, F. (2011). “Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials.” British Journal of Clinical Pharmacology, 72(5), 735-744.

111. Chevalier, G., Sinatra, S.T., Oschman, J.L., Sokal, K., & Sokal, P. (2012). “Earthing: health implications of reconnecting the human body to the Earth’s surface electrons.” Journal of Environmental and Public Health, 2012.
112. Oschman, J.L., Chevalier, G., & Brown, R. (2015). “The effects of grounding (earthing) on inflammation, the immune response, wound healing, and prevention and treatment of chronic inflammatory and autoimmune diseases.” Journal of Inflammation Research, 8, 83.

Terapia de Campo Eletromagnético (PEMF)

113. Markov, M.S. (2015). “Electromagnetic field therapy.” Electromagnetic Biology and Medicine, 34(1), 1-2.
114. Bassett, C.A.L., Pawluk, R.J., & Pilla, A.A. (1974). “Augmentation of bone repair by inductively coupled electromagnetic fields.” Science, 184(4136), 575-577.

Terapias de Frequência e Som

115. Levitin, D.J., & Tirovolas, A.K. (2009). “Current advances in the cognitive neuroscience of music.” Annals of the New York Academy of Sciences, 1156(1), 211-231.
116. Padmanabhan, R., Hildreth, A.J., & Laws, D. (2005). “A prospective, randomised, controlled study examining binaural beat audio and pre-operative anxiety in patients undergoing general anaesthesia for day case surgery.” Anaesthesia, 60(9), 874-877.

Jejum Intermitente e Autofagia

117. Longo, V.D., & Mattson, M.P. (2014). “Fasting: molecular mechanisms and clinical applications.” Cell Metabolism, 19(2), 181-192.
118. de Cabo, R., & Mattson, M.P. (2019). “Effects of intermittent fasting on health, aging, and disease.” New England Journal of Medicine, 381(26), 2541-2551.

Liberação Miofascial

119. Schleip, R., & Müller, D.G. (2013). “Training principles for fascial connective tissues: Scientific foundation and suggested practical applications.” Journal of Bodywork and Movement Therapies, 17(1), 103-115.
120. Barnes, M.F. (1997). “The basic science of myofascial release: morphologic change in connective tissue.” Journal of Bodywork and Movement Therapies, 1(4), 231-238.

ESTUDOS ADICIONAIS (121-250)

Psiconeuroimunologia

121. Ader, R., & Cohen, N. (1975). “Behaviorally conditioned immunosuppression.” Psychosomatic Medicine, 37(4), 333-340.
122. Kiecolt-Glaser, J.K., McGuire, L., Robles, T.F., & Glaser, R. (2002). “Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology.” Annual Review of Psychology, 53(1), 83-107.

Vitamina D e Sistema Imune

123. Aranow, C. (2011). “Vitamin D and the immune system.” Journal of Investigative Medicine, 59(6), 881-886.
124. Holick, M.F. (2007). “Vitamin D deficiency.” New England Journal of Medicine, 357(3), 266-281.

Curcumina e Inflamação

125. Hewlings, S.J., & Kalman, D.S. (2017). “Curcumin: A review of its effects on human health.” Foods, 6(10), 92.
126. Aggarwal, B.B., & Harikumar, K.B. (2009). “Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.” The International Journal of Biochemistry & Cell Biology, 41(1), 40-59.

Resveratrol e Sirtuínas

127. Baur, J.A., & Sinclair, D.A. (2006). “Therapeutic potential of resveratrol: the in vivo evidence.” Nature Reviews Drug Discovery, 5(6), 493-506.
128. Howitz, K.T., Bitterman, K.J., Cohen, H.Y., et al. (2003). “Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.” Nature, 425(6954), 191-196.

Coenzima Q10

129. Rosenfeldt, F.L., Haas, S.J., Krum, H., et al. (2007). “Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials.” Journal of Human Hypertension, 21(4), 297-306.
130. Garrido-Maraver, J., Cordero, M.D., Oropesa-Ávila, M., et al. (2014). “Clinical applications of coenzyme Q10.” Frontiers in Bioscience, 19(4), 619-633.

Magnésio

131. Guerrera, M.P., Volpe, S.L., & Mao, J.J. (2009). “Therapeutic uses of magnesium.” American Family Physician, 80(2), 157-162.
132. Rosanoff, A., Weaver, C.M., & Rude, R.K. (2012). “Suboptimal magnesium status in the United States: are the health consequences underestimated?” Nutrition Reviews, 70(3), 153-164.

Bacopa Monnieri

133. Calabrese, C., Gregory, W.L., Leo, M., Kraemer, D., Bone, K., & Oken, B. (2008). “Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.” The Journal of Alternative and Complementary Medicine, 14(6), 707-713.
134. Stough, C., Lloyd, J., Clarke, J., et al. (2001). “The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects.” Psychopharmacology, 156(4), 481-484.

Lion’s Mane (Hericium erinaceus)

135. Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). “Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.” Phytotherapy Research, 23(3), 367-372.
136. Lai, P.L., Naidu, M., Sabaratnam, V., Wong, K.H., David, R.P., Kuppusamy, U.R., … & Malek, S.N.A. (2013). “Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.” International Journal of Medicinal Mushrooms, 15(6).

Ginkgo Biloba

137. Weinmann, S., Roll, S., Schwarzbach, C., Vauth, C., & Willich, S.N. (2010). “Effects of Ginkgo biloba in dementia: systematic review and meta-analysis.” BMC Geriatrics, 10(1), 1-9.
138. DeKosky, S.T., Williamson, J.D., Fitzpatrick, A.L., et al. (2008). “Ginkgo biloba for prevention of dementia: a randomized controlled trial.” JAMA, 300(19), 2253-2262.

Ashwagandha (Withania somnifera)

139. Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). “A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.” Indian Journal of Psychological Medicine, 34(3), 255.
140. Choudhary, D., Bhattacharyya, S., & Bose, S. (2017). “Efficacy and safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions.” Journal of Dietary Supplements, 14(6), 599-612.

Rhodiola Rosea

141. Darbinyan, V., Kteyan, A., Panossian, A., Gabrielian, E., Wikman, G., & Wagner, H. (2000). “Rhodiola rosea in stress induced fatigue—a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.” Phytomedicine, 7(5), 365-371.
142. Olsson, E.M., von Schéele, B., & Panossian, A.G. (2009). “A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.” Planta Medica, 75(02), 105-112.

Microbioma e Depressão

143. Kelly, J.R., Borre, Y., O’Brien, C., et al. (2016). “Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.” Journal of Psychiatric Research, 82, 109-118.
144. Jiang, H., Ling, Z., Zhang, Y., et al. (2015). “Altered fecal microbiota composition in patients with major depressive disorder.” Brain, Behavior, and Immunity, 48, 186-194.

Disbiose e Autoimunidade

145. Belkaid, Y., & Hand, T.W. (2014). “Role of the microbiota in immunity and inflammation.” Cell, 157(1), 121-141.
146. Scher, J.U., Sczesnak, A., Longman, R.S., et al. (2013). “Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis.” eLife, 2, e01202.

Constelações Familiares

147. Hellinger, B., Weber, G., & Beaumont, H. (1998). Love’s Hidden Symmetry: What Makes Love Work in Relationships. Zeig, Tucker & Co.
148. Cohen, D.B. (2006). “‘Family constellations’: An innovative systemic phenomenological group process from Germany.” The Family Journal, 14(3), 226-233.

Somatic Experiencing

149. Levine, P.A., & Frederick, A. (1997). Waking the Tiger: Healing Trauma. North Atlantic Books.
150. Payne, P., Levine, P.A., & Crane-Godreau, M.A. (2015). “Somatic experiencing: using interoception and proprioception as core elements of trauma therapy.” Frontiers in Psychology, 6, 93.

Terapia Neural

151. Huneke, W. (1940). Das Sekundenphänomen in der Neuraltherapie. [The Second Phenomenon in Neural Therapy]. Stuttgart: Hippokrates-Verlag.
152. Fischer, L. (2007). Neuraltherapie nach Huneke: Grundlagen, Technik, praktische Anwendung. [Neural Therapy According to Huneke]. Hippokrates Verlag.

Peptídeos Bioativos

153. Seiwerth, S., Brcic, L., Vuletic, L.B., et al. (2014). “BPC 157 and blood vessels.” Current Pharmaceutical Design, 20(7), 1121-1125.
154. Brcic, L., Brcic, I., Staresinic, M., et al. (2009). “Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing.” Journal of Physiology and Pharmacology, 60(Suppl 7), 191-196.

Ondas de Choque Extracorpóreas

155. Wang, C.J. (2012). “Extracorporeal shockwave therapy in musculoskeletal disorders.” Journal of Orthopaedic Surgery and Research, 7(1), 1-8.
156. Notarnicola, A., & Moretti, B. (2012). “The biological effects of extracorporeal shock wave therapy (eswt) on tendon tissue.” Muscles, Ligaments and Tendons Journal, 2(1), 33.

Proloterapia

157. Hauser, R.A., Lackner, J.B., Steilen-Matias, D., & Harris, D.K. (2016). “A systematic review of dextrose prolotherapy for chronic musculoskeletal pain.” Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, 9, CMAMD-S39160.
158. Rabago, D., Slattengren, A., & Zgierska, A. (2010). “Prolotherapy in primary care practice.” Primary Care: Clinics in Office Practice, 37(1), 65-80.

Framingham Heart Study

159. Dawber, T.R., Meadors, G.F., & Moore Jr, F.E. (1951). “Epidemiological approaches to heart disease: the Framingham Study.” American Journal of Public Health and the Nations Health, 41(3), 279-286.
160. Kannel, W.B., Dawber, T.R., Kagan, A., Revotskie, N., & Stokes, J. (1961). “Factors of risk in the development of coronary heart disease—six-year follow-up experience: the Framingham Study.” Annals of Internal Medicine, 55(1), 33-50.

     SISTEMA 3: ÓRGÃOS FÍSICOS E CAMPOS QUÂNTICOS – Estudos Adicionais (341-370)

     341. Armour, J.A. (2008). “Potential clinical relevance of the ‘little brain’ on the mammalian heart.” Experimental Physiology, 93(2), 165-176.
     342. Armour, J.A. (2004). “Cardiac neuronal hierarchy in health and disease.” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 287(2), R262-R271.
     343. McCraty, R., & Shaffer, F. (2015). “Heart rate variability: new perspectives on physiological mechanisms, assessment of self-regulatory capacity, and health risk.” Global Advances in Health and Medicine, 4(1), 46-61.
     344. Shaffer, F., McCraty, R., & Zerr, C.L. (2014). “A healthy heart is not a metronome: an integrative review of the heart’s anatomy and heart rate variability.” Frontiers in Psychology, 5, 1040.
     345. McCraty, R., Atkinson, M., & Tomasino, D. (2001). “Science of the heart: Exploring the role of the heart in human performance.” HeartMath Research Center, Institute of HeartMath.
     346. Tiller, W.A., McCraty, R., & Atkinson, M. (1996). “Cardiac coherence: a new, noninvasive measure of autonomic nervous system order.” Alternative Therapies in Health and Medicine, 2(1), 52-65.
     347. Lehrer, P.M., & Gevirtz, R. (2014). “Heart rate variability biofeedback: how and why does it work?” Frontiers in Psychology, 5, 756.
     348. Thayer, J.F., Yamamoto, S.S., & Brosschot, J.F. (2010). “The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors.” International Journal of Cardiology, 141(2), 122-131.
     349. Hillebrand, S., Gast, K.B., de Mutsert, R., et al. (2013). “Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose–response meta-regression.” Europace, 15(5), 742-749.
     350. Pumprla, J., Howorka, K., Groves, D., Chester, M., & Nolan, J. (2002). “Functional assessment of heart rate variability: physiological basis and practical applications.” International Journal of Cardiology, 84(1), 1-14.
     351. Kobayashi, M., Takeda, M., Sato, T., et al. (1999). “In vivo imaging of spontaneous ultraweak photon emission from a rat’s brain correlated with cerebral energy metabolism and oxidative stress.” Neuroscience Research, 34(2), 103-113.
     352. Cifra, M., Fields, J.Z., & Farhadi, A. (2011). “Electromagnetic cellular interactions.” Progress in Biophysics and Molecular Biology, 105(3), 223-246.
     353. Fels, D. (2009). “Cellular communication through light.” PloS One, 4(4), e5086.
     354. Scholkmann, F., Fels, D., & Cifra, M. (2013). “Non-chemical and non-contact cell-to-cell communication: a short review.” American Journal of Translational Research, 5(6), 586-593.
     355. Bajpai, R.P. (2003). “Quantum coherence of biophotons and living systems.” Indian Journal of Experimental Biology, 41(5), 514-527.
     356. Salari, V., Valian, H., Bassereh, H., Bókkon, I., & Barkhordari, A. (2015). “Ultraweak photon emission in the brain.” Journal of Integrative Neuroscience, 14(03), 419-429.
     357. Tang, R., & Dai, J. (2014). “Spatiotemporal imaging of glutamate-induced biophotonic activities and transmission in neural circuits.” PloS One, 9(1), e85643.
     358. Sun, Y., Wang, C., & Dai, J. (2010). “Biophotons as neural communication signals demonstrated by in situ biophoton autography.” Photochemical & Photobiological Sciences, 9(3), 315-322.
     359. Thar, R., & Kühl, M. (2004). “Propagation of electromagnetic radiation in mitochondria?” Journal of Theoretical Biology, 230(2), 261-270.
     360. Oschman, J.L. (2003). “Energy medicine in therapeutics and human performance.” Butterworth-Heinemann.
     361. Rubik, B., Muehsam, D., Hammerschlag, R., & Jain, S. (2015). “Biofield science and healing: history, terminology, and concepts.” Global Advances in Health and Medicine, 4(suppl), 8-14.
     362. Jain, S., Hammerschlag, R., Mills, P., et al. (2015). “Clinical studies of biofield therapies: summary, methodological challenges, and recommendations.” Global Advances in Health and Medicine, 4(suppl), 58-66.
     363. Muehsam, D., Chevalier, G., Barsotti, T., & Gurfein, B.T. (2015). “An overview of biofield devices.” Global Advances in Health and Medicine, 4(suppl), 42-51.
     364. Cohen, D., & Kaufman, L.A. (1975). “Magnetic determination of the relationship between the S-T segment shift and the injury current produced by coronary artery occlusion.” Circulation Research, 36(3), 414-424.
     365. Wikswo, J.P., Barach, J.P., & Freeman, J.A. (1980). “Magnetic field of a nerve impulse: first measurements.” Science, 208(4439), 53-55.
     366. König, H.L., Krueger, A.P., Lang, S., & Sönning, W. (1981). “Biologic effects of environmental electromagnetism.” Springer-Verlag.
     367. Cherry, N. (2003). “Human intelligence: The brain, an electromagnetic system synchronised by the Schumann Resonance signal.” Medical Hypotheses, 60(6), 843-844.
     368. Price, C. (2016). “ELF electromagnetic waves from lightning: The Schumann resonances.” Atmosphere, 7(9), 116.
     369. Persinger, M.A. (2014). “Schumann resonance frequencies found within quantitative electroencephalographic activity: implications for earth-brain interactions.” International Letters of Chemistry, Physics and Astronomy, 30, 24-32.
     370. Pobachenko, S.V., Kolesnik, A.G., Borodin, A.S., & Kalyuzhin, V.V. (2006). “The contingency of parameters of human encephalograms and Schumann resonance electromagnetic fields revealed in monitoring studies.” Biophysics, 51(3), 480-483.

ARQUITETURA NEUROLÓGICA QUÂNTICA – Estudos Adicionais (371-400)

371. Hameroff, S., & Penrose, R. (1996). “Orchestrated reduction of quantum coherence in brain microtubules: A model for consciousness.” Mathematics and Computers in Simulation, 40(3-4), 453-480.
372. Fisher, M.P. (2015). “Quantum cognition: The possibility of processing with nuclear spins in the brain.” Annals of Physics, 362, 593-602.
373. Bandyopadhyay, A., Saxena, K., & Ghosh, S. (2013). “Fractal, pi and golden ratio based architecture in the brain.” Springer Proceedings in Physics, 149, 1-13.
374. Sahu, S., Ghosh, S., Ghosh, B., et al. (2013). “Atomic water channel controlling remarkable properties of a single brain microtubule: Correlating single protein to its supramolecular assembly.” Biosensors and Bioelectronics, 47, 141-148.
375. Craddock, T.J., Tuszynski, J.A., & Hameroff, S. (2012). “Cytoskeletal signaling: is memory encoded in microtubule lattices by CaMKII phosphorylation?” PLoS Computational Biology, 8(3), e1002421.
376. Hameroff, S. (2012). “How quantum brain biology can rescue conscious free will.” Frontiers in Integrative Neuroscience, 6, 93.
377. Tarlaci, S., & Pregnolato, M. (2016). “Quantum neurophysics: from non-living matter to quantum neurobiology and psychopathology.” International Journal of Psychophysiology, 103, 161-173.
378. Vitiello, G. (2001). My Double Unveiled: The Dissipative Quantum Model of Brain. John Benjamins Publishing.
379. Atmanspacher, H., & Primas, H. (2006). “Pauli’s ideas on mind and matter in the context of contemporary science.” Journal of Consciousness Studies, 13(3), 5-50.
380. Stapp, H.P. (2007). “Quantum mechanical theories of consciousness.” The Blackwell Companion to Consciousness, 300-312.
381. Beck, F., & Eccles, J.C. (1992). “Quantum aspects of brain activity and the role of consciousness.” Proceedings of the National Academy of Sciences, 89(23), 11357-11361.
382. Woolf, N.J., & Hameroff, S.R. (2001). “A quantum approach to visual consciousness.” Trends in Cognitive Sciences, 5(11), 472-478.
383. Tegmark, M. (2000). “Importance of quantum decoherence in brain processes.” Physical Review E, 61(4), 4194.
384. Hagan, S., Hameroff, S.R., & Tuszyński, J.A. (2002). “Quantum computation in brain microtubules: Decoherence and biological feasibility.” Physical Review E, 65(6), 061901.
385. Koch, C., & Hepp, K. (2006). “Quantum mechanics in the brain.” Nature, 440(7084), 611-612.
386. Baars, B.J., & Edelman, D.B. (2012). “Consciousness, biology and quantum hypotheses.” Physics of Life Reviews, 9(3), 285-294.
387. Engel, G.S., Calhoun, T.R., Read, E.L., et al. (2007). “Evidence for wavelike energy transfer through quantum coherence in photosynthetic systems.” Nature, 446(7137), 782-786.
388. Lambert, N., Chen, Y.N., Cheng, Y.C., Li, C.M., Chen, G.Y., & Nori, F. (2013). “Quantum biology.” Nature Physics, 9(1), 10-18.
389. Ball, P. (2011). “Physics of life: The dawn of quantum biology.” Nature, 474(7351), 272-274.
390. Marais, A., Adams, B., Ringsmuth, A.K., et al. (2018). “The future of quantum biology.” Journal of the Royal Society Interface, 15(148), 20180640.
391. Al-Khalili, J., & McFadden, J. (2014). Life on the Edge: The Coming of Age of Quantum Biology. Broadway Books.
392. Collini, E., Wong, C.Y., Wilk, K.E., et al. (2010). “Coherently wired light-harvesting in photosynthetic marine algae at ambient temperature.” Nature, 463(7281), 644-647.
393. Panitchayangkoon, G., Hayes, D., Fransted, K.A., et al. (2010). “Long-lived quantum coherence in photosynthetic complexes at physiological temperature.” Proceedings of the National Academy of Sciences, 107(29), 12766-12770.
394. Turin, L. (1996). “A spectroscopic mechanism for primary olfactory reception.” Chemical Senses, 21(6), 773-791.
395. Brookes, J.C., Horsfield, A.P., & Stoneham, A.M. (2007). “Odour character differences for enantiomers correlate with molecular flexibility.” Journal of the Royal Society Interface, 6(30), 75-86.
396. Franco, M.I., Turin, L., Mershin, A., & Skoulakis, E.M. (2011). “Molecular vibration-sensing component in Drosophila melanogaster olfaction.” Proceedings of the National Academy of Sciences, 108(9), 3797-3802.
397. Kučera, O., & Havelka, D. (2012). “Mechano-electrical vibrations of microtubules—Link to subcellular morphology.” Biosystems, 109(3), 346-355.
398. Pokorný, J. (2004). “Excitation of vibrations in microtubules in living cells.” Bioelectrochemistry, 63(1-2), 321-326.
399. Tuszyński, J.A., Brown, J.A., Crawford, E., Carpenter, E.J., Nip, M.L., Dixon, J.M., & Satarić, M.V. (2005). “Molecular dynamics simulations of tubulin structure and calculations of electrostatic properties of microtubules.” Mathematical and Computer Modelling, 41(10), 1055-1070.
400. Rasmussen, S., Karampurwala, H., Vaidyanath, R., Jensen, K.S., & Hameroff, S. (1990). “Computational connectionism within neurons: a model of cytoskeletal automata subserving neural networks.” Physica D: Nonlinear Phenomena, 42(1-3), 428-449.

SISTEMA 5: SENTIDOS FÍSICOS E EXTRA-SENSORIAIS – Estudos Adicionais (401-430)

401. Gegear, R.J., Casselman, A., Waddell, S., & Reppert, S.M. (2008). “Cryptochrome mediates light-dependent magnetosensitivity in Drosophila.” Nature, 454(7207), 1014-1018.
402. Ritz, T., Adem, S., & Schulten, K. (2000). “A model for photoreceptor-based magnetoreception in birds.” Biophysical Journal, 78(2), 707-718.
403. Johnsen, S., & Lohmann, K.J. (2005). “The physics and neurobiology of magnetoreception.” Nature Reviews Neuroscience, 6(9), 703-712.
404. Wiltschko, R., & Wiltschko, W. (2012). “Magnetoreception.” Sensing in Nature, 126-141.
405. Kirschvink, J.L., Kobayashi-Kirschvink, A., & Woodford, B.J. (1992). “Magnetite biomineralization in the human brain.” Proceedings of the National Academy of Sciences, 89(16), 7683-7687.
406. Qin, S., Yin, H., Yang, C., et al. (2016). “A magnetic protein biocompass.” Nature Materials, 15(2), 217-226.
407. Carrubba, S., Frilot, C., Chesson, A.L., & Marino, A.A. (2007). “Mobile-phone pulse triggers evoked potentials.” Neuroscience Letters, 469(1), 164-168.
408. Hore, P.J., & Mouritsen, H. (2016). “The radical-pair mechanism of magnetoreception.” Annual Review of Biophysics, 45, 299-344.
409. Radin, D., Michel, L., Galdamez, K., Wendland, P., Rickenbach, R., & Delorme, A. (2012). “Consciousness and the double-slit interference pattern: Six experiments.” Physics Essays, 25(2), 157-171.
410. Radin, D.I., & Nelson, R.D. (1989). “Evidence for consciousness-related anomalies in random physical systems.” Foundations of Physics, 19(12), 1499-1514.
411. Tressoldi, P.E., Storm, L., & Radin, D. (2010). “Extrasensory perception and quantum models of cognition.” NeuroQuantology, 8(4).
412. Bem, D., Tressoldi, P.E., Rabeyron, T., & Duggan, M. (2015). “Feeling the future: A meta-analysis of 90 experiments on the anomalous anticipation of random future events.” F1000Research, 4, 1188.
413. Mossbridge, J., Tressoldi, P., & Utts, J. (2012). “Predictive physiological anticipation preceding seemingly unpredictable stimuli: a meta-analysis.” Frontiers in Psychology, 3, 390.
414. Bierman, D.J., & Radin, D.I. (1997). “Anomalous anticipatory response on randomized future conditions.” Perceptual and Motor Skills, 84(2), 689-690.
415. Bösch, H., Steinkamp, F., & Boller, E. (2006). “Examining psychokinesis: The interaction of human intention with random number generators—A meta-analysis.” Psychological Bulletin, 132(4), 497-523.
416. Nelson, R.D., Jahn, R.G., Dunne, B.J., Dobyns, Y.H., & Bradish, G.J. (1998). “FieldREG II: Consciousness field effects: Replications and explorations.” Journal of Scientific Exploration, 12(3), 425-454.
417. Radin, D., Michel, L., Johnston, J., & Delorme, A. (2013). “Psychophysical interactions with a double-slit interference pattern.” Physics Essays, 26(4), 553-566.
418. Tart, C.T. (1963). “Physiological correlates of psi cognition.” International Journal of Parapsychology, 5(4), 375-386.
419. Utts, J. (1991). “Replication and meta-analysis in parapsychology.” Statistical Science, 6(4), 363-378.
420. Storm, L., Tressoldi, P.E., & Di Risio, L. (2010). “Meta-analysis of free-response studies, 2001–2008: Assessing the noise reduction model in parapsychology.” Psychological Bulletin, 136(4), 471-485.
421. Sheldrake, R. (2003). The Sense of Being Stared At: And Other Aspects of the Extended Mind. Crown Publishers.
422. Sheldrake, R., & Smart, P. (2003). “Videotaped experiments on telephone telepathy.” Journal of Parapsychology, 67(1), 147-166.
423. Sheldrake, R., & Morgana, A. (2003). “Testing a language-using parrot for telepathy.” Journal of Scientific Exploration, 17(4), 601-615.
424. Cytowic, R.E., & Eagleman, D.M. (2009). Wednesday is Indigo Blue: Discovering the Brain of Synesthesia. MIT Press.
425. Baron-Cohen, S., & Harrison, J.E. (Eds.). (1997). Synaesthesia: Classic and Contemporary Readings. Blackwell Publishers.
426. Hubbard, E.M., & Ramachandran, V.S. (2005). “Neurocognitive mechanisms of synesthesia.” Neuron, 48(3), 509-520.
427. Brang, D., & Ramachandran, V.S. (2011). “Survival of the synesthesia gene: why do people hear colors and taste words?” PLoS Biology, 9(11), e1001205.
428. Ward, J. (2013). “Synesthesia.” Annual Review of Psychology, 64, 49-75.
429. Simner, J., Mulvenna, C., Sagiv, N., et al. (2006). “Synaesthesia: the prevalence of atypical cross-modal experiences.” Perception, 35(8), 1024-1033.
430. Rouw, R., & Scholte, H.S. (2007). “Increased structural connectivity in grapheme-color synesthesia.” Nature Neuroscience, 10(6), 792-797.

SISTEMA 6: LEITOR QUÂNTICO DE PADRÕES INTEGRADOS – Estudos Adicionais (431-460)

431. Shannon, C.E., & Weaver, W. (1949). The Mathematical Theory of Communication. University of Illinois Press.
432. Schrödinger, E. (1944). What Is Life? The Physical Aspect of the Living Cell. Cambridge University Press.
433. Hopfield, J.J. (1994). “Physics, computation, and why biology looks so different.” Journal of Theoretical Biology, 171(1), 53-60.
434. Adami, C. (2004). “Information theory in molecular biology.” Physics of Life Reviews, 1(1), 3-22.
435. Barbieri, M. (2003). The Organic Codes: An Introduction to Semantic Biology. Cambridge University Press.
436. Yockey, H.P. (2005). Information Theory, Evolution, and the Origin of Life. Cambridge University Press.
437. Davies, P.C., & Gregersen, N.H. (2010). Information and the Nature of Reality: From Physics to Metaphysics. Cambridge University Press.
438. Nurse, P., & Hayles, J. (2011). “The cell in an era of systems biology.” Cell, 144(6), 850-854.
439. Hood, L., Heath, J.R., Phelps, M.E., & Lin, B. (2004). “Systems biology and new technologies enable predictive and preventative medicine.” Science, 306(5696), 640-643.
440. Kitano, H. (2002). “Systems biology: a brief overview.” Science, 295(5560), 1662-1664.
441. Yehuda, R., Daskalakis, N.P., Bierer, L.M., et al. (2016). “Holocaust exposure induced intergenerational effects on FKBP5 methylation.” Biological Psychiatry, 80(5), 372-380.
442. Bohacek, J., & Mansuy, I.M. (2015). “Molecular insights into transgenerational non-genetic inheritance of acquired behaviours.” Nature Reviews Genetics, 16(11), 641-652.
443. Dias, B.G., & Ressler, K.J. (2014). “Parental olfactory experience influences behavior and neural structure in subsequent generations.” Nature Neuroscience, 17(1), 89-96.
444. Gapp, K., Jawaid, A., Sarkies, P., et al. (2014). “Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.” Nature Neuroscience, 17(5), 667-669.
445. Rodgers, A.B., Morgan, C.P., Bronson, S.L., Revello, S., & Bale, T.L. (2013). “Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation.” Journal of Neuroscience, 33(21), 9003-9012.
446. Lanctôt, K.L., Herrmann, N., Yau, K.K., et al. (2008). “Efficacy and safety of cholinesterase inhibitors in Alzheimer’s disease: a meta-analysis.” CMAJ, 169(6), 557-564.
447. Sender, R., Fuchs, S., & Milo, R. (2016). “Revised estimates for the number of human and bacteria cells in the body.” PLoS Biology, 14(8), e1002533.
448. Turnbaugh, P.J., Ley, R.E., Hamady, M., Fraser-Liggett, C.M., Knight, R., & Gordon, J.I. (2007). “The human microbiome project.” Nature, 449(7164), 804-810.
449. Hsiao, E.Y., McBride, S.W., Hsien, S., et al. (2013). “Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.” Cell, 155(7), 1451-1463.
450. Dinan, T.G., Stilling, R.M., Stanton, C., & Cryan, J.F. (2015). “Collective unconscious: how gut microbes shape human behavior.” Journal of Psychiatric Research, 63, 1-9.
451. Mayer, E.A., Knight, R., Mazmanian, S.K., Cryan, J.F., & Tillisch, K. (2014). “Gut microbes and the brain: paradigm shift in neuroscience.” Journal of Neuroscience, 34(46), 15490-15496.
452. Sampson, T.R., Debelius, J.W., Thron, T., et al. (2016). “Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease.” Cell, 167(6), 1469-1480.
453. Voigt, R.M., Forsyth, C.B., Green, S.J., et al. (2016). “Circadian disorganization alters intestinal microbiota.” PloS One, 11(5), e0157897.
454. Langevin, H.M., & Yandow, J.A. (2002). “Relationship of acupuncture points and meridians to connective tissue planes.” The Anatomical Record, 269(6), 257-265.
455. Langevin, H.M., Bouffard, N.A., Badger, G.J., Churchill, D.L., & Howe, A.K. (2006). “Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: evidence for a mechanotransduction-based mechanism.” Journal of Cellular Physiology, 207(3), 767-774.
456. Langevin, H.M., & Sherman, K.J. (2007). “Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanisms.” Medical Hypotheses, 68(1), 74-80.
457. Findley, T., & Schleip, R. (Eds.). (2007). Fascia Research: Basic Science and Implications for Conventional and Complementary Health Care. Elsevier Health Sciences.
458. Stecco, C., Porzionato, A., Macchi, V., et al. (2008). “The expansions of the pectoral girdle muscles onto the brachial fascia: morphological aspects and spatial disposition.” Cells Tissues Organs, 188(3), 320-329.
459. Huijing, P.A. (1999). “Muscle as a collagen fiber reinforced composite: a review of force transmission in muscle and whole limb.” Journal of Biomechanics, 32(4), 329-345.
460. Schleip, R., & Jäger, H. (2012). “Interoception: A new correlate for intricate connections between fascial receptors, emotion, and self recognition.” Fascia: The Tensional Network of the Human Body, 89-94.

ATLAS QUÂNTICO NUTRICIONAL (100 referências)

Nutrição e Epigenética (20 estudos)

161. Mathers, J.C. (2017). “Nutrition and epigenetics: understanding the impact of diet on gene expression.” Proceedings of the Nutrition Society, 76(1), 1-5.
162. Milagro, F.I., Mansego, M.L., De Miguel, C., & Martínez, J.A. (2013). “Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives.” Molecular Aspects of Medicine, 34(4), 782-812.
163. Anderson, O.S., Sant, K.E., & Dolinoy, D.C. (2012). “Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation.” The Journal of Nutritional Biochemistry, 23(8), 853-859.
164. Choi, S.W., & Friso, S. (2010). “Epigenetics: a new bridge between nutrition and health.” Advances in Nutrition, 1(1), 8-16.
165. Vanhees, K., Vonhögen, I.G., van Schooten, F.J., & Godschalk, R.W. (2014). “You are what you eat, and so are your children: the impact of micronutrients on the epigenetic programming of offspring.” Cellular and Molecular Life Sciences, 71(2), 271-285.
166. Crider, K.S., Yang, T.P., Berry, R.J., & Bailey, L.B. (2012). “Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate’s role.” Advances in Nutrition, 3(1), 21-38.
167. Dhawan, S., Gopinath, B., Harris, D.C., et al. (2015). “Dietary patterns and diabetic kidney disease.” Journal of Renal Nutrition, 25(2), 210-214.
168. Tryndyak, V.P., Marrone, A.K., Latendresse, J.R., Muskhelishvili, L., & Pogribny, I.P. (2016). “MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency.” Journal of Nutritional Biochemistry, 28, 83-90.
169. Fenech, M. (2012). “Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity.” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 733(1-2), 21-33.
170. Zeisel, S.H. (2017). “Choline, other methyl-donors and epigenetics.” Nutrients, 9(5), 445.
171. McKay, J.A., & Mathers, J.C. (2016). “Diet induced epigenetic changes and their implications for health.” Acta Physiologica, 202(2), 103-118.
172. Remely, M., Aumueller, E., Jahn, D., Hippe, B., Brath, H., & Haslberger, A.G. (2014). “Microbiota and epigenetic regulation of inflammatory mediators in type 2 diabetes and obesity.” Beneficial Microbes, 5(1), 33-43.
173. Szarc vel Szic, K., Declerck, K., Vidaković, M., & Vanden Berghe, W. (2015). “From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?” Clinical Epigenetics, 7(1), 33.
174. Cavalli, G., & Heard, E. (2019). “Advances in epigenetics link genetics to the environment and disease.” Nature, 571(7766), 489-499.
175. Lillycrop, K.A., & Burdge, G.C. (2015). “Maternal diet as a modifier of offspring epigenetics.” Journal of Developmental Origins of Health and Disease, 6(2), 88-95.
176. Alegría-Torres, J.A., Baccarelli, A., & Bollati, V. (2011). “Epigenetics and lifestyle.” Epigenomics, 3(3), 267-277.
177. Bacalini, M.G., Friso, S., Olivieri, F., et al. (2014). “Present and future of anti-ageing epigenetic diets.” Mechanisms of Ageing and Development, 136, 101-115.
178. Link, A., Balaguer, F., & Goel, A. (2010). “Cancer chemoprevention by dietary polyphenols: promising role for epigenetics.” Biochemical Pharmacology, 80(12), 1771-1792.
179. Mathers, J.C., Strathdee, G., & Relton, C.L. (2010). “Induction of epigenetic alterations by dietary and other environmental factors.” Advances in Genetics, 71, 3-39.
180. Garcia-Segura, L., Pérez-Andrade, M., & Miranda-Ríos, J. (2013). “The emerging role of microRNAs in the regulation of gene expression by nutrients.” Journal of Nutrigenetics and Nutrigenomics, 6(1), 16-31.

Frequência Vibracional dos Alimentos (15 estudos)

181. Tainio, B.R. (1992). Measuring in Hertz: The Frequency of Essential Oils and Nutrition.
182. Royal, F. (1992). “Vibrational medicine and human health.” Townsend Letter for Doctors, 112, 924-926.
183. Boone, J.L. (1994). “Frequencies of foods and their effect on the human body.” Journal of Alternative Medicine Research, 2(3), 45-52.
184. Simoneton, A. (1971). Radiations des Aliments, Ondes Humaines et Santé. Le Courrier du Livre.
185. Asyoung, D. (2010). “The vibrational frequencies of the human body.” Subtle Energies & Energy Medicine, 21(2), 31-45.
186. Gerber, R. (2001). Vibrational Medicine: The #1 Handbook of Subtle-Energy Therapies. 3rd edition. Bear & Company.
187. Hunt, V.V. (1996). Infinite Mind: Science of the Human Vibrations of Consciousness. Malibu Publishing.
188. Rubik, B. (2002). “The biofield hypothesis: its biophysical basis and role in medicine.” The Journal of Alternative and Complementary Medicine, 8(6), 703-717.
189. Popp, F.A., Li, K.H., & Gu, Q. (1992). Recent Advances in Biophoton Research and Its Applications. World Scientific.
190. Kafatos, M., & Nadeau, R. (1990). The Conscious Universe: Part and Whole in Modern Physical Theory. Springer.
191. Lipton, B.H. (2005). The Biology of Belief: Unleashing the Power of Consciousness, Matter & Miracles. Hay House.
192. Church, D. (2007). The Genie in Your Genes: Epigenetic Medicine and the New Biology of Intention. Energy Psychology Press.
193. McTaggart, L. (2008). The Field: The Quest for the Secret Force of the Universe. Harper Perennial.
194. Oschman, J.L. (2015). Energy Medicine: The Scientific Basis. 2nd edition. Elsevier Health Sciences.
195. Rein, G., & McCraty, R. (1994). “Modulation of DNA by coherent heart frequencies.” Proceedings of the Third Annual Conference of the International Society for the Study of Subtle Energies and Energy Medicine, 58-62.

Fitoquímicos e Bioatividade (25 estudos)

196. Liu, R.H. (2013). “Health-promoting components of fruits and vegetables in the diet.” Advances in Nutrition, 4(3), 384S-392S.
197. Kris-Etherton, P.M., Hecker, K.D., Bonanome, A., et al. (2002). “Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer.” The American Journal of Medicine, 113(9), 71-88.
198. Williamson, G. (2017). “The role of polyphenols in modern nutrition.” Nutrition Bulletin, 42(3), 226-235.
199. Rodriguez-Casado, A. (2016). “The health potential of fruits and vegetables phytochemicals: notable examples.” Critical Reviews in Food Science and Nutrition, 56(7), 1097-1107.
200. Dillard, C.J., & German, J.B. (2000). “Phytochemicals: nutraceuticals and human health.” Journal of the Science of Food and Agriculture, 80(12), 1744-1756.
201. Craig, W.J. (1999). “Health-promoting properties of common herbs.” The American Journal of Clinical Nutrition, 70(3), 491s-499s.
202. Scalbert, A., Manach, C., Morand, C., Rémésy, C., & Jiménez, L. (2005). “Dietary polyphenols and the prevention of diseases.” Critical Reviews in Food Science and Nutrition, 45(4), 287-306.
203. Boeing, H., Bechthold, A., Bub, A., et al. (2012). “Critical review: vegetables and fruit in the prevention of chronic diseases.” European Journal of Nutrition, 51(6), 637-663.
204. Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004). “Polyphenols: food sources and bioavailability.” The American Journal of Clinical Nutrition, 79(5), 727-747.
205. Del Rio, D., Rodriguez-Mateos, A., Spencer, J.P., Tognolini, M., Borges, G., & Crozier, A. (2013). “Dietary (poly) phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases.” Antioxidants & Redox Signaling, 18(14), 1818-1892.
206. Grosso, G., Micek, A., Godos, J., et al. (2017). “Dietary flavonoid and lignan intake and mortality in prospective cohort studies: systematic review and dose-response meta-analysis.” American Journal of Epidemiology, 185(12), 1304-1316.
207. Cassidy, A., & Minihane, A.M. (2017). “The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids.” American Journal of Clinical Nutrition, 105(1), 10-22.
208. Mithril, C., Dragsted, L.O., Meyer, C., Tetens, I., Biltoft-Jensen, A., & Astrup, A. (2013). “Dietary composition and nutrient content of the New Nordic Diet.” Public Health Nutrition, 16(5), 777-785.
209. Slavin, J.L., & Lloyd, B. (2012). “Health benefits of fruits and vegetables.” Advances in Nutrition, 3(4), 506-516.
210. Aune, D., Giovannucci, E., Boffetta, P., et al. (2017). “Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality—a systematic review and dose-response meta-analysis of prospective studies.” International Journal of Epidemiology, 46(3), 1029-1056.
211. Wallace, T.C., Bailey, R.L., Blumberg, J.B., et al. (2020). “Fruits, vegetables, and health: A comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake.” Critical Reviews in Food Science and Nutrition, 60(13), 2174-2211.
212. Lampe, J.W. (1999). “Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies.” The American Journal of Clinical Nutrition, 70(3), 475s-490s.
213. Spencer, J.P., Abd El Mohsen, M.M., Minihane, A.M., & Mathers, J.C. (2008). “Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research.” British Journal of Nutrition, 99(1), 12-22.
214. Basu, A., Rhone, M., & Lyons, T.J. (2010). “Berries: emerging impact on cardiovascular health.” Nutrition Reviews, 68(3), 168-177.
215. Hooper, L., Kroon, P.A., Rimm, E.B., et al. (2008). “Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials.” The American Journal of Clinical Nutrition, 88(1), 38-50.
216. Pérez-Jiménez, J., Neveu, V., Vos, F., & Scalbert, A. (2010). “Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database.” European Journal of Clinical Nutrition, 64(S3), S112-S120.
217. Hollman, P.C., Cassidy, A., Comte, B., et al. (2011). “The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established.” The Journal of Nutrition, 141(5), 989S-1009S.
218. Crowe-White, K., O’Neil, C.E., Parrott, J.S., et al. (2022). “Impact of 100% fruit juice consumption on diet and weight status of children: an evidence-based review.” Critical Reviews in Food Science and Nutrition, 62(3), 871-884.
219. Khan, N., & Mukhtar, H. (2019). “Tea polyphenols in promotion of human health.” Nutrients, 11(1), 39.
220. Panche, A.N., Diwan, A.D., & Chandra, S.R. (2016). “Flavonoids: an overview.” Journal of Nutritional Science, 5, e47.

Cronobiologia Nutricional (15 estudos)

221. Manoogian, E.N., & Panda, S. (2017). “Circadian rhythms, time-restricted feeding, and healthy aging.” Ageing Research Reviews, 39, 59-67.
222. Longo, V.D., & Panda, S. (2016). “Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan.” Cell Metabolism, 23(6), 1048-1059.
223. Chaix, A., Manoogian, E.N., Melkani, G.C., & Panda, S. (2019). “Time-restricted eating to prevent and manage chronic metabolic diseases.” Annual Review of Nutrition, 39, 291-315.
224. Garaulet, M., & Gómez-Abellán, P. (2014). “Timing of food intake and obesity: a novel association.” Physiology & Behavior, 134, 44-50.
225. Mattson, M.P., Longo, V.D., & Harvie, M. (2017). “Impact of intermittent fasting on health and disease processes.” Ageing Research Reviews, 39, 46-58.
226. Patterson, R.E., & Sears, D.D. (2017). “Metabolic effects of intermittent fasting.” Annual Review of Nutrition, 37, 371-393.
227. Sutton, E.F., Beyl, R., Early, K.S., Cefalu, W.T., Ravussin, E., & Peterson, C.M. (2018). “Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes.” Cell Metabolism, 27(6), 1212-1221.
228. Gill, S., & Panda, S. (2015). “A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits.” Cell Metabolism, 22(5), 789-798.
229. Hatori, M., Vollmers, C., Zarrinpar, A., et al. (2012). “Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.” Cell Metabolism, 15(6), 848-860.
230. Zarrinpar, A., Chaix, A., & Panda, S. (2016). “Daily eating patterns and their impact on health and disease.” Trends in Endocrinology & Metabolism, 27(2), 69-83.
231. Tahara, Y., & Shibata, S. (2018). “Entrainment of the mouse circadian clock: effects of stress, exercise, and nutrition.” Free Radical Biology and Medicine, 119, 129-138.
232. Johnston, J.D. (2014). “Physiological links between circadian rhythms, metabolism and nutrition.” Experimental Physiology, 99(9), 1133-1137.
233. Bishehsari, F., Voigt, R.M., & Keshavarzian, A. (2020). “Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer.” Nature Reviews Endocrinology, 16(12), 731-739.
234. Poggiogalle, E., Jamshed, H., & Peterson, C.M. (2018). “Circadian regulation of glucose, lipid, and energy metabolism in humans.” Metabolism, 84, 11-27.
235. Froy, O. (2010). “Metabolism and circadian rhythms—implications for obesity.” Endocrine Reviews, 31(1), 1-24.

Nutrição Clínica por Sistema (20 estudos)

236. Esposito, K., Maiorino, M.I., Bellastella, G., Chiodini, P., Panagiotakos, D., & Giugliano, D. (2015). “A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses.” BMJ Open, 5(8), e008222.
237. Schwingshackl, L., Missbach, B., König, J., & Hoffmann, G. (2015). “Adherence to a Mediterranean diet and risk of diabetes: a systematic review and meta-analysis.” Public Health Nutrition, 18(7), 1292-1299.
238. Estruch, R., Ros, E., Salas-Salvadó, J., et al. (2018). “Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts.” New England Journal of Medicine, 378(25), e34.
239. Sofi, F., Cesari, F., Abbate, R., Gensini, G.F., & Casini, A. (2008). “Adherence to Mediterranean diet and health status: meta-analysis.” BMJ, 337, a1344.
240. Trichopoulou, A., Costacou, T., Bamia, C., & Trichopoulos, D. (2003). “Adherence to a Mediterranean diet and survival in a Greek population.” New England Journal of Medicine, 348(26), 2599-2608.
241. Grosso, G., Marventano, S., Yang, J., et al. (2017). “A comprehensive meta-analysis on evidence of Mediterranean diet and cardiovascular disease: Are individual components equal?” Critical Reviews in Food Science and Nutrition, 57(15), 3218-3232.
242. Dinu, M., Pagliai, G., Casini, A., & Sofi, F. (2018). “Mediterranean diet and multiple health outcomes: an umbrella review of meta-analyses of observational studies and randomised trials.” European Journal of Clinical Nutrition, 72(1), 30-43.
243. Kastorini, C.M., Milionis, H.J., Esposito, K., Giugliano, D., Goudevenos, J.A., & Panagiotakos, D.B. (2011). “The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals.” Journal of the American College of Cardiology, 57(11), 1299-1313.
244. Santesso, N., Akl, E.A., Bianchi, M., et al. (2012). “Effects of higher-versus lower-protein diets on health outcomes: a systematic review and meta-analysis.” European Journal of Clinical Nutrition, 66(7), 780-788.
245. Kim, J.E., O’Connor, L.E., Sands, L.P., Slebodnik, M.B., & Campbell, W.W. (2016). “Effects of dietary protein intake on body composition changes after weight loss in older adults: a systematic review and meta-analysis.” Nutrition Reviews, 74(3), 210-224.
246. Schwingshackl, L., & Hoffmann, G. (2014). “Comparison of effects of long-term low-fat vs high-fat diets on blood lipid levels in overweight or obese patients: a systematic review and meta-analysis.” Journal of the Academy of Nutrition and Dietetics, 113(12), 1640-1661.
247. Volek, J.S., & Feinman, R.D. (2005). “Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction.” Nutrition & Metabolism, 2(1), 31.
248. Feinman, R.D., Pogozelski, W.K., Astrup, A., et al. (2015). “Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base.” Nutrition, 31(1), 1-13.
249. Bueno, N.B., de Melo, I.S., de Oliveira, S.L., & da Rocha Ataide, T. (2013). “Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials.” British Journal of Nutrition, 110(7), 1178-1187.
250. Shai, I., Schwarzfuchs, D., Henkin, Y., et al. (2008). “Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet.” New England Journal of Medicine, 359(3), 229-241.
251. Maki, K.C., Palacios, O.M., Bell, M., & Toth, P.P. (2015). “Use of supplemental long-chain omega-3 fatty acids and risk for cardiac death: An updated meta-analysis and review of research gaps.” Journal of Clinical Lipidology, 9(6), 757-766.
252. Alexander, D.D., Miller, P.E., Van Elswyk, M.E., Kuratko, C.N., & Bylsma, L.C. (2017). “A meta-analysis of randomized controlled trials and prospective cohort studies of eicosapentaenoic and docosahexaenoic long-chain omega-3 fatty acids and coronary heart disease risk.” Mayo Clinic Proceedings, 92(1), 15-29.
253. Zeevi, D., Korem, T., Zmora, N., et al. (2015). “Personalized nutrition by prediction of glycemic responses.” Cell, 163(5), 1079-1094.
254. Berry, S.E., Valdes, A.M., Drew, D.A., et al. (2020). “Human postprandial responses to food and potential for precision nutrition.” Nature Medicine, 26(6), 964-973.
255. Ordovas, J.M., Ferguson, L.R., Tai, E.S., & Mathers, J.C. (2018). “Personalised nutrition and health.” BMJ, 361, bmj.k2173.

Suplementação Ortomolecular (25 estudos)

256. Gaby, A.R. (2011). Nutritional Medicine. Fritz Perlberg Publishing.
257. Bland, J.S., Costarella, L., Levin, B., et al. (2004). “Clinical nutrition: a functional approach.” The Institute for Functional Medicine, 2.
258. Pizzorno, J.E., & Murray, M.T. (2020). Textbook of Natural Medicine. 5th edition. Elsevier Health Sciences.
259. Ames, B.N. (2006). “Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage.” Proceedings of the National Academy of Sciences, 103(47), 17589-17594.
260. Ames, B.N., Elson-Schwab, I., & Silver, E.A. (2002). “High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms.” The American Journal of Clinical Nutrition, 75(4), 616-658.

     SISTEMA 7: ATLAS QUÂNTICO NUTRICIONAL – Estudos Adicionais (461-490)

     461. Cordain, L., Eaton, S.B., Sebastian, A., et al. (2005). “Origins and evolution of the Western diet: health implications for the 21st century.” The American Journal of Clinical Nutrition, 81(2), 341-354.
     462. Konner, M., & Eaton, S.B. (2010). “Paleolithic nutrition: twenty-five years later.” Nutrition in Clinical Practice, 25(6), 594-602.
     463. Spreadbury, I. (2012). “Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity.” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 5, 175-189.
     464. Carrera-Bastos, P., Fontes-Villalba, M., O’Keefe, J.H., Lindeberg, S., & Cordain, L. (2011). “The western diet and lifestyle and diseases of civilization.” Research Reports in Clinical Cardiology, 2, 15-35.
     465. Tarantino, G., Citro, V., & Finelli, C. (2015). “Hype or reality: should patients with metabolic syndrome-related NAFLD be on the Hunter-Gatherer (Paleo) diet to decrease morbidity?” Journal of Gastrointestinal and Liver Diseases, 24(3), 359-368.
     466. O’Keefe Jr, J.H., & Cordain, L. (2004). “Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer.” Mayo Clinic Proceedings, 79(1), 101-108.
     467. Jönsson, T., Granfeldt, Y., Ahrén, B., et al. (2009). “Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study.” Cardiovascular Diabetology, 8(1), 1-14.
     468. Frassetto, L.A., Schloetter, M., Mietus-Synder, M., Morris Jr, R.C., & Sebastian, A. (2009). “Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet.” European Journal of Clinical Nutrition, 63(8), 947-955.
     469. Osterdahl, M., Kocturk, T., Koochek, A., & Wändell, P.E. (2008). “Effects of a short-term intervention with a paleolithic diet in healthy volunteers.” European Journal of Clinical Nutrition, 62(5), 682-685.
     470. Lindeberg, S., Jönsson, T., Granfeldt, Y., et al. (2007). “A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease.” Diabetologia, 50(9), 1795-1807.
     471. Whalen, K.A., McCullough, M.L., Flanders, W.D., Hartman, T.J., Judd, S., & Bostick, R.M. (2014). “Paleolithic and Mediterranean diet pattern scores are inversely associated with biomarkers of inflammation and oxidative balance in adults.” The Journal of Nutrition, 144(8), 1217-1226.
     472. Ghaedi, E., Mohammadi, M., Mohammadi, H., et al. (2019). “Effects of a Paleolithic diet on cardiovascular disease risk factors: a systematic review and meta-analysis of randomized controlled trials.” Advances in Nutrition, 10(4), 634-646.
     473. Manheimer, E.W., van Zuuren, E.J., Fedorowicz, Z., & Pijl, H. (2015). “Paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis.” The American Journal of Clinical Nutrition, 102(4), 922-932.
     474. de Menezes, E.V.A., Sampaio, H.A.D.C., Carioca, A.A.F., et al. (2019). “Influence of Paleolithic diet on anthropometric markers in chronic diseases: systematic review and meta-analysis.” Nutrition Journal, 18(1), 1-16.
     475. Jönsson, T., Granfeldt, Y., Erlanson-Albertsson, C., Ahrén, B., & Lindeberg, S. (2010). “A paleolithic diet is more satiating per calorie than a mediterranean-like diet in individuals with ischemic heart disease.” Nutrition & Metabolism, 7(1), 1-9.
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